Pharmacokinetic/Pharmacodynamic Data Analysis & Modeling

This course will be a unique learning opportunity, using your own laptop computer, to gain a thorough understanding of pharmacokinetic/ pharmacodynamic modeling and related data analysis techniques.

THE COURSE IN CONTEXT

To facilitate a better understanding of the temporal disposition of a drug in vivo, after its administration by whatever route, various ‘models’ may be invoked by the pharmacokinetic analyst. These models differ in complexity and utility varying from a single compartment to more complicated, but physiologically relevant, models which incorporate known blood flow rates through various organs.

Regardless of the efficiency of the model used, however, pharmacokinetic analysis is of limited value if no known link exists between the pharmacokinetic parameters obtained and a drug’s specific effect(s). Thus, in recent years scientists have focused on the integration of pharmacokinetics and pharmacodynamics. For both the bench and clinical pharmaceutical researcher an understanding of PK/PD modeling concepts is essential. (See: Jenny Y. Chien, et al., “Pharmacokinetics/Pharmacodynamics and the Stages of Drug Development: Role of Modeling and Simulation”, The AAPS Journal, 7 (3), E544 – E559, 2005.)

PARTIAL COURSE CONTENTS

 

  • Rationale for modeling data
  • Approaches to modeling and limitations
  • Review of pharmacokinetic models
  • Integration methods using the computer
  • Optimization methods
  • Weighting of data
  • Initial estimates and model description
  • Interpretation of program output
  • Selection of ‘best’ model
  • Optimal sampling (within and between models)
  • Model indentifiability (analytical and numerical)
  • Maximal effect (Emax) pharmacodynamic models
  • Population pharmacokinetics modeling

+ Practical “hands-on” exercises, including:


  • Graphing and ‘PK’ simulations
  • Fitting data and optimization techniques
  • Data weighing practice
  • Using ADAPT II & NONMEM (computer exercises)

PRINCIPAL INSTRUCTOR > David W.A. Bourne, Ph.D.

* All participants receive a powerful pharmacokinetics/ pharmacodynamics modeling software package (“BOOMER” for Windows or Mac).

NOTE:  Please contact us about arranging a special in-house presentation to suit your organization’s specific requirements.